Promethazine with Codeine Oral Resolution really should be used with caution in patients with bone-marrow depression. Leukopenia and agranulocytosis are reported, generally when promethazine has become Employed in Affiliation with other acknowledged marrow-poisonous agents.
To aid protect against withdrawal, your health care provider may reduced your dose bit by bit. Withdrawal is a lot more probably When you've got utilized this medication for a long period (quite a lot of months) or in large doses. Inform your health practitioner or pharmacist at once In case you have withdrawal.
Some Unwanted effects could occur that typically will not have to have medical attention. These Uncomfortable side effects may well go away for the duration of procedure as One's body adjusts on the medication. Also, your health and fitness care Experienced could possibly let you know about techniques to avoid or cut down some of these Unintended effects.
Don't enhance your dose or use this product or service extra frequently or for for a longer time than prescribed. Your situation will not enhance any more rapidly, along with your risk of side effects will boost.
A minimum of just one Loss of life was described in a very nursing infant who was subjected to large levels of morphine in breast milk since the mother was an extremely-quick metabolizer of codeine.
Checking the affected individual for indications and/or symptoms of respiratory despair, cardiac arrhythmias, and narcotic bowel syndrome
Get health care enable at once when you discover any of the following: gradual/shallow respiration, significant drowsiness/problems waking up, confusion.
Making use of this medication with any of the next medicines will likely be not advisable, but could possibly be essential in some instances. If both equally medicines are prescribed alongside one another, your physician could alter the dose or how frequently you use one particular or equally on the medicines.
Whilst substantial heterogeneity exists relating to CYP2D6 enzyme ability within all ethnicities, Hispanic and White people exhibit the very best CYP2D6 "ultrafast metabolizer" features.[21]
If adrenal insufficiency is diagnosed, take care of with physiologic substitute doses of corticosteroids. Wean the affected person off of the opioid to allow adrenal purpose to recover and proceed corticosteroid therapy until eventually adrenal purpose recovers. Other opioids could possibly be tried as some scenarios reported utilization of a distinct opioid without having recurrence of adrenal insufficiency. The knowledge out there isn't going to identify any certain opioids as currently being a lot more likely to be connected with adrenal insufficiency.
A most likely fatal symptom elaborate occasionally often called Neuroleptic Malignant Syndrome (NMS) has become documented in association with promethazine HCl alone or together with antipsychotic medication.
Talk with your medical professional Should you have any questions about taking codeine or about how this drugs may perhaps impact your newborn.
Other Negative effects not listed may additionally arise in certain clients. For those who notice another consequences, Promethazine codeine syrup Look at with all your healthcare Qualified.
Get this medication just as prescribed to decrease the potential risk of addiction. Request your health practitioner or pharmacist For additional aspects.